GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm
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چکیده
منابع مشابه
GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm
Pulmonary alveolar proteinosis (PAP) is classified as autoimmune, secondary, or genetic. We herein describe a 69-year-old man with autoimmune PAP, simultaneously diagnosed with myeloproliferative neoplasm (MPN). Two years after the diagnosis, the MPN progressed to acute myeloid leukemia, and the patient died from an alveolar hemorrhage during remission induction chemotherapy. Throughout the cli...
متن کاملGM-CSF and GM-CSF beta c receptor in adult patients with pulmonary alveolar proteinosis.
Pulmonary alveolar proteinosis (PAP) is a rare disorder of unknown origin characterized by alveolar fillings with periodic acid-Schiff (PAS)-positive material mainly consisting of phospholipids. Mice defective in the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene or the GM-CSF/interleukin (IL)-3/IL-5-receptor common beta chain (beta c) demonstrate a pathology resembling PAP. A r...
متن کاملReduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis.
proportions of obstructive and restrictive airway disease between the main ethnic groups in sarcoidosis, and also the first to report an association of functional impairment with age. Despite a weak evidence base, sarcoidosis patients are often prescribed inhaled corticosteroids and b-agonists for respiratory symptoms regardless of their pattern of lung function at presentation [12]. Large airw...
متن کاملAnti-GM-CSF antibodies in paediatric pulmonary alveolar proteinosis.
BACKGROUND Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of anti-GM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear. METHODS Anti-GM-CSF auto-antibodies were determined with the help of an antigen capture assay using serum and/or bronchoalveo...
متن کاملPulmonary alveolar proteinosis: a complete response to GM-CSF therapy.
Pulmonary alveolar proteinosis is a rare condition traditionally requiring treatment with whole lung lavage. The case is presented of a young man who obtained complete remission following treatment with granulocyte-macrophage colony stimulating factor, a new treatment option.
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2017
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.56.6920